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اعضاء هیئت علمی پژوهشکده بیوتکنولوژی کشاورزی ایران
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شهره آریایی نژاد
استادیار
tel 026-32703536
email sh.ariaee@abrii.ac.ir. shariee@gmail.com
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دوره پسا دکتری خود را تحت حمایت بنیاد ملی نخبگان از سال 1391 تا 1394 ، به طور مشترک در مرکز تحقیقات بیوشیمی- بیوفیزیک (IBB) و گروه بیوتکنولوژی دانشگاه تهران گذراندم. در این مقطع تمرکز اصلی من بر روی تعیین توالی نوکلئوتیدی و آمینو اسیدی پروتئین های جدید، تعیین ساختار و عملکرد آنها و همچنین کریستالوگرافی آنها بوده است.

همچنین دوره دکتری خود را بر روی جداسازی و خالص سازی پروتئین ها، مطالعه ساختار و عملکرد آنها و یادگیری و توسعه تکنیک های مرتبط در این عرصه در مرکز تحقیقات بیوشیمی و بیو فیزیک (IBB) و آزمایشگاه بیوتکنولوژی پروتئین دانشگاه تهران در بهمن ماه 1390به اتمام رساندم.

من مدارک کارشناسی و کارشناسی ارشد خود را در رشته شیمی اخذ کرده ام. در دوره کارشناسی اولین فعالیت های پژوهشی خود در زمینه استخراج ترکیبات موثره طبیعی گیاهان بومی ایران را زیر نظر اساتید برجسته دانشگاه بین المللی امام خمینی  آغاز نموده و این علاقه مندی را در دوره کارشناسی ارشد به صورت جدی تری بر روی استخراج و شناسایی مواد طبیعی از بافت آبزیان ادامه دادم.

از سال 1394 عضو هیات علمی پژوهشگاه بیوتکنولوژی کشاورزی هستم و به مدت شش سال است که در بخش زیست شناسی سامانه ها در پروژه های تحقیقاتی تعریف شده در زمینه شناسایی، تعیین ساختار و عملکرد آنزیم های صنعتی جدید از داده های متاژنوم در حال تحقیق می باشم. نتیجه این تحقیقات منجر به شناسایی آنزیم های نوترکیب زیادی از گروه زایلانازها، سلولازها، پروتئاز و لیپاز و .... گردید و تمام این آنزیم های جدید با نام های ایرانی در پایگاه داداه های جهانی مانند NCBI و مقالات معتبر علمی ثبت شده اند.

شناسایی و معرفی آنزیم های صنعتی جدید با رویکرد مهندسی آنزیم های نوتریکب، بررسی ویژگی های بیوشیمیایی آنزیم های نوترکیب جدید و افزایش خواص عملکرد آنها با تثبیت جهت ارائه به صنعت، از زمینه های تحقیقاتی و مورد علاقه اینجانب می باشد.

 

 

Research Interests

 

  •  Screening of metagenomic data to discover novel stable enzymes

 

  • Characterization of novel enzymes like protease, lipase, xylanase, cellulase, laccase, etc.

 

  • Application of protein engineering to improve catalytic activity of enzymes

 

  • Enzyme immobilization

 

  • Computational analysis of structure-function relationship of proteins/enzymes

 

 

 

Publications:

Journal publications

 

* corresponding or co-corresponding author

 

Lignocellulose degradation by rumen bacterial communities: New insights from metagenome analyses

 

Gharechahi J., Vahidi M.F., Sharifi G., Ariaeenejad S., Ding X, Han J., Hosseini Salekdeh Gh

 

Environmental Research,

115925, (2023)

Efficiency of an alkaline, thermostable, detergent compatible and organic solvent tolerant lipase with hydrolytic potential in biotreatment of wastewater

 

Ariaeenejad S.*, Kavousi K., Han JL., Ding XZ., Salekdeh GH.

 

Science of The Total Environment, 161066, (2023)

 

Efficient bioconversion of lignocellulosic waste by a novel computationally screened hyperthermostable enzyme from a specialized microbiota

 

Ariaeenejad S.*, Kavousi K., Zolfaghari B., Roy S, Koshiba T, Hosseini Salekdeh Gh.

 

Ecotoxicology and environmental safety

114587, (2023)

Simultaneous hydrolysis of various protein-rich industrial wastes by a naturally evolved protease from tannery wastewater microbiota

 

Ariaeenejad S.*, Kavousi K., Abdollahzadeh Mamaghani A.S., Ghasemitabesh R., Hosseini Salekdeh Gh.,

 

Science of The Total Environment, 152796, (2022)

 

Enzymatically triggered delignification through a novel stable laccase: A mixed in-silico/in-vitro exploration of a complex environmental microbiota

 

Ariaeenejad S.*, Kavousi K., Afshar Jahanshahi D, Abdollahzadeh Mamaghani A.S., Ghasemitabesh R., Moosavi-Movahedi, A.A, Hosseini Salekdeh Gh.,

 

International Journal of Biological Macromolecules, 328-341, (2022)

Highly efficient removal of dyes from wastewater using nanocellulose from quinoa husk as a carrier for immobilization of laccase

 

Ariaeenejad S*., Motamedi E., Hosseini Salekdeh Gh.,

 

Bioresource Technology, 126833, (2022)

Enhancing the ethanol production by exploiting a novel metagenomic-derived bifunctional xylanase/β-glucosidase enzyme with improved β-glucosidase activity by a nanocellulose carrier

 

Ariaeenejad S.*, Motamedi E., Kavousi K., Ghasemitabesh R., Goudarzi R., Zolfaghari B., Roy S, Hosseini Salekdeh Gh.

 

Frontiers in microbiology, 13: 1056364, (2022)

Synthesis of two novel bio-based hydrogels using sodium alginate and chitosan and their proficiency in physical immobilization of enzymes

 

Shakeri F., Ariaeenejad S., Ghollasi M., Motamedi E

 

Scientific Reports, 12, 1-14, (2022)

In vitro bioprocessing of corn as poultry feed additive by the influence of carbohydrate hydrolyzing metagenome derived enzyme cocktail

 

Mousavi S.H., Sadeghian Motahar S.F., Salami M., Kavousi K., Sheykh Abdollahzadeh Mamaghani A., Ariaeenejad S.*, Hosseini Salekdeh Gh

 

Scientific Reports, 12, 1-14 (2022)

A computational learning paradigm to targeted discovery of biocatalysts from metagenomic data: A case study of lipase identification

 

Kavousi K., Foroozandeh Shahraki M., Fallah Atanaki F., Ariaeenejad S., Ghaffari M.R., Norouzi‐Beirami M.H., Maleki M., Hosseini Salekdeh Gh

 

Biotechnology and Bioengineering, 1115-1128, (2022)

Efficient saccharification of ionic liquid-pretreated rice straw in a one-pot system using novel metagenomics derived cellulases

 

Maleki M., Ariaeenejad S., Hosseini Salekdeh Gh

Bioresource Technology, 126536, (2022)

Synergistic Effect of Metagenome‐Derived Starch‐Degrading Enzymes on Quality of Functional Bread with Antioxidant Activity

 

Sadeghian Motahar S.F., Salami M., Ariaeenejad S.*, Emam‐Djomeh Z., Sheykh Abdollahzadeh Mamaghani A., Kavousi K., Moghadam M., Hosseini Salekdeh Gh

 

  1. Starch‐Stärke, 74, 2100098, (2022)

 

The novel homologue of the human α‐glucosidase inhibited by the non‐germinated and germinated quinoa protein hydrolysates after in vitro gastrointestinal digestion

 

Salami M., Sadeghian Motahar S.F., Ariaeenejad S.*, Abdollahzadeh Mamaghani A.S., Kavousi K., Moosavi‐Movahedi Ali A, Hosseini Salekdeh Gh

 

Journal of Food Biochemistry, e14030 (2021)

Efficient removal of various textile dyes from wastewater by novel thermo-halotolerant laccase

 

Motamedi E., Kavousi K., Sadeghian Motahar F., Mohammad Reza Ghaffari, Sheykh Abdollahzadeh Mamaghani A., Hosseini Salekdeh Gh., Ariaeenejad S.*

 

Bioresource Technology, 337,125468 (2021)

 

 

Application of free and immobilized novel bifunctional biocatalyst in biotransformation of recalcitrant lignocellulosic biomass

 

Ariaeenejad S.*, Kavousi K., Maleki M., Motamedi E., Moosavi-Movahedi A.A., Hosseini Salekdeh Gh

 

Chemosphere, 285,131412 (2021)

Highly Efficient Computationally Derived Novel Metagenome α-Amylase with Robust Stability Under Extreme Denaturing Conditions

 

Ariaeenejad S.*, Zolfaghari B, Sadeghian Motahar, F, Kavousi K., Maleki M., Roy, S., Hosseini Salekdeh Gh

 

Frontiers in microbiology, 713125, (2021)

Immobilization of enzyme cocktails on dopamine functionalized magnetic cellulose nanocrystals to enhance sugar bioconversion: A biomass reusing loop

 

Ariaeenejad S., Motamedi E., Hosseini Salekdeh Gh

 

Carbohydrate Polymers, 256, 117511.

 

In-silico discovery of bifunctional enzymes with enhanced lignocellulose hydrolysis from microbiota big data

 

Ariaeenejad S.*, Kavousi K., Sheykh Abdollahzadeh Mamaghani A., Sadeghian Motahar F., Nedaei H., Hosseini Salekdeh Gh

 

International Journal of Biological Macromolecules, 177,211-220 (2021)

  1.  

Upgrading the enzymatic hydrolysis of lignocellulosic biomass by immobilization of metagenome-derived novel halotolerant cellulase on the carboxymethyl cellulose-based hydrogel

 

Elaheh Motamedi E, Sadeghian Motahar S.F., Maleki M., Kavousi K., Ariaeenejad S.*, Moosavi-Movahedi A.A., Hosseini Salekdeh Gh.

 

Cellulose, 28(6), 3485-3503

(2021)

Improving the quality of gluten-free bread by a novel acidic thermostable α-amylase from metagenomics data

 

Sadeghian Motahar S.F., Ariaeenejad S.*, Salami M., Emam-Djomeh Z., Sheykh Abdollahzadeh Mamaghani A

 

Food Chemistry, 352,129307. (2021)

Application of the immobilized enzyme on magnetic graphene oxide nano-carrier as a versatile bi-functional tool for efficient removal of dye from water

 

Ariaeenejad S., Motamedi E., Hosseini Salekdeh Gh.,

 

Bioresource Technology, 319, 124228. (2021)

MCIC: automated identification of cellulases from metagenomic data and characterization based on temperature and pH dependence

 

Foroozandeh Shahraki M, Ariaeenejad S., Fallah Atanaki F., Zolfaghari B., Koshiba T., Kavousi K., Hosseini Salekdeh Gh

 

Frontiers in microbiology, 567863, (2020)

A generalized machine‐learning aided method for targeted identification of industrial enzymes from metagenome: A xylanase temperature dependence case study

 

Foroozandeh Shahraki M, Farhadyar K, Kavousi K. Ariaeenejad S.*, Hosseini Salekdeh Gh.

 

Biotechnology and Bioengineering, 759-769, (2021)

A novel high performance in-silico screened metagenome-derived alkali-thermostable endo-β-1, 4-glucanase for lignocellulosic biomass hydrolysis in the harsh conditions

 

Ariaeenejad S.*, Sheykh Abdollahzadeh Mamaghani A., Maleki M., Kavousi K., Foroozandeh Shahraki M., Hosseini Salekdeh Gh

 

BMC biotechnology, 20 (1-13). (2020)

An efficient nano-biocatalyst for lignocellulosic biomass hydrolysis: Xylanase immobilization on organically modified biogenic mesoporous silica nanoparticles

 

Ariaeenejad S. *, Jokar F., Hadian P., Ma'mani L., Gharaghani S., Fereidoonnezhad M., Hosseini Salekdeh Gh

 

International Journal of Biological Macromolecules, 164 (3462-3473). (2020)

 

A novel metagenome-derived thermostable and poultry feed compatible α-amylase with enhanced biodegradation properties

 

Sadeghian Motahar S.F., Khatibi A., Salami M., Ariaeenejad S.*, Emam-Djomeh A., Nedaei H., Kavousi K., Sheykhabdolahzadeh Mamaghani A., Hosseini Salekdeh Gh

 

International Journal of Biological Macromolecules, 164 (2124-2133) (2020)

Improvement of PersiXyn2 activity and stability in presence of Trehalose and proline as a natural osmolyte

 

Norouzi S., Hajati Birgani N., Maghami P., Ariaeenejad S.*

 

International Journal of Biological Macromolecules, 163 (348-357).

IAMPE: NMR-Assisted Computational Prediction of Antimicrobial Peptides

 

Kavousi K., Bagheri M., Behrouzi S, Vafadar S., Fallah Atanaki F., Teimouri Lotfabadi B., Ariaeenejad S., Shockravi A., Moosavi-Movahedi A.A.,

 

Journal of Chemical Information and Modeling, 60 (10) 4691-4701.

 

 

A novel high glucose-tolerant β-Glucosidase: targeted computational approach for metagenomic screening

 

Ariaeenejad S.*, Nooshi-Nedamani S., Rahban M., Kavousi K., Ghasemi Pirbalooti A., MirghaderiS.S., Mohammadi M., Mirzaei M., Hosseini Salekdeh Gh.

 

Frontiers in bioengineering and biotechnology, (8) 831. (2020)

 

The stabilizing mechanism of immobilized metagenomic xylanases on bio-based hydrogels to improve utilization performance: computational and functional perspectives

 

Ariaeenejad S.*, Lanjanian H., Motamedi E., Kavousi K., Moosavi-Movahedi A.A, Hosseini Salekdeh Gh.

 

Bioconjugate Chemistry, 31 (9) 2158-2171

(2020)

BIPEP: Sequence-based Prediction of Biofilm Inhibitory Peptides Using a Combination of NMR and Physicochemical Descriptors

 

Fallah Atanaki F., Behrouzi S., Ariaeenejad S., Boroomand A., Kavousi K.

 

ACS Omega. 5(13) 7290-7297 (2020)

 

co-abundance analysis reveals hidden players associated with high methane yield phenotype in sheep rumen microbiome

 

Ghanbari Maman L., Palizban F., Fallah Atanaki F., Elmi Ghiasi N., Ariaeenejad S., Reza Ghaffari R., Hosseini Salekdeh Gh., Kavousi K,

 

Scientific Reports. 10 (1-12).

(2020),

A novel thermostable cellulase cocktail enhances lignocellulosic bioconversion and biorefining in a broad range of pH

 

Maleki M., Foroozandeh Shahraki M., Kavousi K., Ariaeenejad S.*

 

International Journal of Biological Macromolecules, 349-360 (2020)

Stable cellulase immobilized on graphene oxide@ CMC-g-poly (AMPS-co-AAm) hydrogel for enhanced enzymatic hydrolysis of lignocellulosic biomass

 

Maleki M., Foroozandeh Shahraki M., Kavousi K., Ariaeenejad S.*.,

 

), International Journal of Biological Macromolecules, 349-360

(2020)

Application of carboxymethyl cellulose-g-poly (acrylic acid-co-acrylamide) hydrogel sponges for improvement of efficiency, reusability and thermal stability of a recombinant xylanase

 

Ariaeenejad S., Hosseini E., Motamedi E., Moosavi-Movahedi A.A., Hosseini Salekdeh Gh.,

 

Chemical Engineering Journal. 375,122022.

(2019)

Mining of camel rumen metagenome to identify novel alkali-thermostable xylanase capable of enhancing the recalcitrant lignocellulosic biomass conversion

 

Ariaeenejad S., Maleki M., Hosseini E., Kavousi K., Moosavi-Movahedi A.A., Hosseini Salekdeh Gh.,

 

Bioresource technology. 281(343-350).

 

(2019)

Identification and characterization of a novel thermostable xylanase from camel rumen metagenome

 

Ariaeenejad S.*, Hosseini E., Maleki M., Kavousi K., Moosavi-Movahedi A.A., Hosseini Salekdeh Gh.,

 

International journal of biological macromolecules.126 (1295-1302), (2019)

Novel X-ray Sequences and Crystal Structures of Persian and Starry Sturgeon Methemoglobin: Highlighting the Role of Heme Pocket Waters in causing autoxidation

 

Seyedarabi S, Ariaeenejad S., Moosavi-Movahedi A.A., Rayati S., Poursasan N., Asiaie N., Seraj Z., Mehraban F., Seyedarabi S.E

 

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 6(586-594).

(2019)

 

The impact of slaughtering methods on physicochemical characterization of sheep myoglobin.

 

Hosseini E., Sattari R., Ariaeenejad S., Salami M., Emam-Djomeh Z., Fotouhi L., Poursasan N., Sheibani N., Ghamsari S., Moosavi-Movahedi A.A.,

 

Journal of the Iranian Chemical Society, 2(315-324). (2019)

A computational method for prediction of xylanase enzymes activity in strains of Bacillus subtilis based on pseudo amino acid composition features

 

Ariaeenejad S., Mousivand M., Moradi Dezfouli P., Hashemi M., Kavousi K., Hosseini Salekdeh Gh.

 

PloS one, (2018)

Time–frequency approach in the cluster assignment of amino acids based on their NMR profiles

 

Shockravi A., Kavousi K., Rezania J., Jafari R., Norouzi Beirami M.H., Ariaeenejad S., Moosavi-Movahedi Z., Maghami P., Mortazavian A.M., Moosavi Movahedi A.A

 

Journal of the Iranian Chemical Society, (2017)

Effects of zinc binding on the structure and thermal stability of camel alpha-lactalbumin

 

Atri M.S., Saboury Ali A., Moosavi-Movahedi A.A., Kavousi K., Ariaeenejad S.,

 

Journal of Thermal Analysis and Calorimetry, 120 (481-488). (2015)

 

The species and heme pocket properties of Sturgeon hemoglobins upon interaction with n-dodecyl trimethylammonium bromide

 

Ariaeenejad S., Moosavi-Movahedi A.A., Kavousi K., Dayer MR., Hong J., Yousefi R., Sheibani N., Habibi-Rezaei M.,

 

Protein & Peptide Letters, 21(171-178). (2014)

Denaturation and intermediates study of two sturgeon hemoglobins by n-dodecyl trimethylammonium bromide

 

Ariaeenejad S., Habibi-Rezaei M., Kavousi K., Jamili Sh., Fatemi MR., Hong J., Poursasan N., Sheibani N., Moosavi-Movahedi A.A.,

International Journal of Biological Macromolecules, 53 (107– 113).

(2013)

Effect of compatible and noncompatible osmolytes on the enzymatic activity and thermal stability of bovine liver catalase

 

H. Sepasi Tehrani, A.A. Moosavi-Movahedi , H. Ghourchian , F. Ahmad , A. Kiany, M.S. Atri , Ariaeenejad S., K. Kavousi  & A.A. Saboury

Journal of Biomolecular Structure and Dynamics, 1440-1454, (2012)

The role of trehalose for metastable state and functional form of recombinant interferon beta-1b

 

Fazeli A., Shojaosadati SA., Fazeli MR., Khalifeh K., Ariaeenejad S., Moosavi-Movahedi A.A.

Journal of Biotechnology, 163 (318–324). (2013)

Effect of Compatible and Non-compatible Osmolytes on the Enzymatic Activity and Thermal Stability of Bovine Liver Catalase

 

Sepasi Tehrani H., Moosavi-Movahedi Ali A., Ghourchian H., Ahmad F., Kiany A., Atri MS., Ariaeenejad S., Kavousi K., Saboury Ali A.,

Journal of Biomolecular Structure and Dynamics, 31(1440–1454).

(2013)

Biochemical Characterization of Hemoglobins from Caspian Sea Sturgeons (Acipenser persicus and Acipenser stellatus)

 

Ariaeenejad S., Habibi-Rezaei M., Kavousi K., Jamili Sh., Fatemi MR., Faizan A., Poursasan N., Sheibani N., Moosavi-Movahedi A.A

Journal of the Cell Biochemistry and Biophysics, 62(73-81).

(2012)

Omega-3 fatty acids composition and lipid content from liver and muscle tissues of Esox lucius in the Caspian Sea (Anzali Port)

 

Samiee K., Rustaiyan A., Ariaeenejad S.

Life Science Journal, 10(167-170). (2010)

 

 

  •  
     

    Distinctions and Awards

     

    Distinguished researcher award from the Alborz Research and Technology Festival

    2022

    Distinguished faculty member of the Agricultural Biotechnology Research Institute of Iran (ABRII)

     

    2020

    Best Innovative Idea Award at “The first event of the leading scientific discourse (gap): Women's ideas and experiences in science and technology”, Iranian National Commission for UNESCO

     

    2020

    National Institutes of Health (NIH) (NIHMS483589, Publ.ID: BIOMAC3424)

     

    2013

     

    The Top Student with 1st rank in MSc. Degree

     

    2006

 

 

 

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